Neutrons in Biology
نویسنده
چکیده
Investigation of Large-scale Biological Structures using Neutrons" (Dick Wettenhall, U. of Melbourne). There were also talks from prominent NMR practitioners and X-ray protein crystallographers, with substantial discussion about how the various methods might fit together in the future. Significant progress was made on defining Australia's needs, which include a strong push to use SANS and reflectometry for the study of macromolecular complexes and model membranes, and a modest network of supporting infrastructure in Brisbane, Melbourne and the Sydney Basin. A watching brief should be kept on the technology of protein crystallography with neutrons, though this should not be an initial emphasis, and there was also some discussion of the dynamics of water in biological systems. Specific Recommendations were that: 1. the small-angle neutron scattering and reflectometry instruments in the RRR be pursued with high priority 2. there be no specific effort to provide high-resolution protein-crystallography facilities at the RRR, but that a watching brief be kept on instrumentation and sample-preparation technologies elsewhere. 3. that a watch be kept on inelastic and quasielastic neutron scattering capabilities elsewhere, although these methods will not initially be pursued at the RRR. 4. there be input from this community into the design of the biochemistry/chemistry laboratories at the Replacement Research Reactor. 5. a small number of regional facilities be established (or enhanced) to allow users to perform deuteration of biomolecules. These facilities would be of significant value to the NMR and neutron scattering communities
منابع مشابه
Comparison of the effects of various cyclotron-produced fast neutrons on the reproductive capacity of cultured human kidney (T-1) cells.
متن کامل
Oncogenic transformation in C3H10T1/2 cells by low-energy neutrons.
PURPOSE Occupational exposure to neutrons typically includes significant doses of low-energy neutrons, with energies below 100 keV. In addition, the normal-tissue dose from boron neutron capture therapy will largely be from low-energy neutrons. Microdosimetric theory predicts decreasing biological effectiveness for neutrons with energies below about 350 keV compared with that for higher-energy ...
متن کاملFast neutrons in the treatment of salivary gland tumors.
Fast neutrons were used in the management of thirty patients with advanced salivary gland tumors. Twentytwo patients are the subject of this analysis. In only seven patients neutrons were used as the primary mode of management. The remaining patients either had recurrent disease after surgery and/or radiation, or received post-operative treatment with neutrons. After a minimum follow-up of one ...
متن کاملRBE-dose relations for neutrons and pions.
From cellular radiosensitivity parameters and theoretical particle-energy spectra in tissue, of the secondary particles from neutron and negative pion irradiations, RBE-Dose relations have been calculated. The theoretical results are compared with clinical and radiobiological data for normal tissue, tumours and cells in culture. Formulae for calculation, cellular parameters and the needed prope...
متن کاملThe response of Geant4 hadronic models to the study of neutrons produced in proton irradiation to the light materials
Neutron is one of the products of the interaction of high energy protons with light nuclei. Using computational Monte Carlo codes, it is possible to calculate and predict the neutron spectrum, neutron flux, and doses by simulating the system. But the use of different hadronic models in this process can influence the results of these calculations. In this research, the response of the four hadro...
متن کاملInvestigation of Developed Shield Composition to Neutron Shielding in Treatment Room for BNCT to Reduce Clinical Effects
Background and Aim: One of the best radiotherapy methods that have been suggested for the treatment of cancers such as brain, head and neck, skin, and recently liver is boron neutron capture therapy. Therefore, neutron shielding in the treatment room is important because the absorption of neutrons in the shield may lead to the production of gamma rays, which can have destructive effects. While ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2001